Genvinset® HLA B27v5 is a semi-automated in vitro diagnostic kit for HLA-B*27 group of alleles qualitative detection in genomic DNA extracted from whole blood, associated with ankylosing spondylitis predisposition, by Real-Time PCR using TaqMan® probes technology.

The major histocompatibility complex (MHC) is the genetic region that contains the most polymorphic loci of the human genome. It is involved in the mechanism of antigen presentation and, as such, defines the general immunological response.

Within the MHC, the allelic family HLA-B*27 is part of the HLA-B locus. The frequency of individuals carrying HLA-B*27 varies widely across populations, being approximately 7-9% in Caucasians.

Patients who can benefit from this determination are those referred by a specialist with clinical symptoms compatible with rheumatoid diseases such as ankylosing spondylitis, reactive arthritis, psoriatic arthritis or juvenile enthesitis related arthritis, and acute anterior uveitis.

The results of this test should not be the only ones on which the therapeutic decision is based and should be used as an aid in the diagnosis together with results of other markers of the disease.